Supercharged precision killers: Genetically engineered biomimetic drugs of screened metalloantibiotics against Acinetobacter baumanni.

To eliminate multidrug-resistant bacteria of Acinetobacter baumannii, we screened 1100 Food and Drug Administration-approved small molecule drugs and accessed the broxyquinoline (Bq) efficacy in combination with various metal ions. Antibacterial tests demonstrated that the prepared Zn(Bq)2 complex showed ultralow minimum inhibitory concentration of ~0.21 micrograms per milliliter with no resistance after 30 passages. We then constructed the nano zeolitic imidazolate framework-8 (ZIF-8) as a drug carrier of Zn(Bq)2 and also incorporated the photosensitizer chlorin e6 (Ce6) to trace and boost the antibacterial effect. To further ensure the stable and targeted delivery, we genetically engineered outer membrane vesicles (OMVs) with the ability to selectively target A. baumannii. By coating the ZnBq/Ce6@ZIF-8 core with these OMV, the resulted drug (ZnBq/Ce6@ZIF-8@OMV) exhibited exceptional killing efficacy (>99.9999999%) of A. baumannii. In addition, in vitro and in vivo tests were also respectively carried out to inspect the remarkable efficacy of this previously unknown nanodrug in eradicating A. baumannii infections, including biofilms and meningitis.

Wavelength-tunable spatiotemporal mode-locking in a large-mode-area Er:ZBLAN fiber laser at 2.8†µm.

We report a tunable spatiotemporally mode-locked large-mode-area Er:ZBLAN fiber laser based on the nonlinear polarization rotation technique. A diffraction grating is introduced to select the operating wavelength. Under the spectral and spatial filtering effects provided by the grating and spatial coupling respectively, stable ps-level spatiotemporally mode-locked pulses around 2.8 µm with a repetition rate of 43.4 MHz are generated. Through a careful adjustment of the grating, a broad wavelength tuning range from 2747 to 2797 nm is realized. To the best of our knowledge, this is the first wavelength-tunable spatiotemporally mode-locked fiber laser in the mid-infrared region.

Over 3.8 W, 3.4†µm picosecond mid-infrared parametric conversion based on a simplified one-to-many scheme.

In this paper, we demonstrate a simplified one-to-many scheme for efficient mid-infrared (MIR) parametric conversion. Such a scheme is based on a continuous wave (CW) single longitudinal mode master oscillator power-amplifier (MOPA) fiber system as the signal source and a picosecond pulsed MOPA fiber system, exhibiting multiple longitudinal modes, as the pump source. The signal and pump beams are combined and co-coupled into a piece of 50-mm long 5% MgO-doped PPLN crystal for the parametric conversion. As high as ∼3.82 W average power at a central idler wavelength of ∼3.4 µm is achieved when the launched pump and signal powers are ∼41.73 and ∼11.45 W, respectively. Above some threshold value, the delivered idler power shows a roll-over effect against the signal power and saturation-like effect against the pump power. Consequently, the highest conversion efficiency is observed at such a threshold pump power. To the best of our knowledge, our result represents the highest average power produced from any single-pass parametric conversion source with >3 µm idler wavelength feeding with a CW signal. Moreover, our proposed scheme can simplify the design of parametric conversion system significantly and meanwhile make the system more robust in applications. This is attributed to two main aspects. Firstly, the scheme's one-to-many feature can reduce wavelength sensitivity remarkably in the realization of quasi-phase-matching. Secondly, for moderate power requirement it does not always require a high peak power synchronized pulsed signal source; a CW one can be an alternative, thereby making the system free from complex time synchronization and the related time jitter.

Revealing Strong Flexoelectricity and Optoelectronic Coupling in 2D Ferroelectric CuInP2S6 Via Large Strain Gradient.

The interplay between flexoelectric and optoelectronic characteristics provides a paradigm for studying emerging phenomena in various 2D materials. However, an effective way to induce a large and tunable strain gradient in 2D devices remains to be exploited. Herein, we propose a strategy to induce large flexoelectric effect in 2D ferroelectric CuInP2S6 by constructing a 1D-2D mixed-dimensional heterostructure. The strong flexoelectric effect is induced by enormous strain gradient up to 4.2 × 106 m-1 resulting from the underlying ZnO nanowires, which is further confirmed by the asymmetric coercive field and the red-shift in the absorption edge. The induced flexoelectric polarization efficiently boosts the self-powered photodetection performance. In addition, the improved photoresponse has a good correlation with the induced strain gradient, showing a consistent size-dependent flexoelectric effect. The mechanism of flexoelectric and optoelectronic coupling is proposed based on the Landau-Ginzburg-Devonshire double-well model, supported by density functional theory (DFT) calculations. This work provides a brand-new method to induce a strong flexoelectric effect in 2D materials, which is not restricted to crystal symmetry and thus offers unprecedented opportunities for state-of-the-art 2D devices.

Patterned Manipulated Surface Based on Femtosecond Laser with Adjustable Wetting Speed and Directional Fluid Delivery.

Recently, due to the crucial roles of multifunctional liquid manipulation surfaces in biomedical transportation, microfluidics, and chemical engineering, the demand for controllable and functional aspects of directed liquid transportation has increased significantly. However, designing an intelligent manipulation surface that is easy to manufacture and fully functional remains an immense challenge. To address this challenge, a smart surface that can regulate the rate of liquid transport within a patterned channel by temperature is reported. A synergistically controlled approach of poly(N-isopropylacrylamide) and micropillar shape-memory polymers (SMPs) was used to modulate the wetting rate of liquids on surfaces. By femtosecond laser direct writing, temperature-responsive composite surfaces are embedded in the microstructure of shape-memory polymers (SMPs) in a patterned manner, resulting in the preparation of novel programmable liquid manipulation surfaces incorporating boundaries possessing asymmetric wettability. Since the smart surface is based on SMP, the superhydrophobic part in the superhydrophobic/controllable wettability patterning platform is also programmed for droplet directional transport, which takes advantage of the difference in wettability between the rewritable indentation track and the periphery to allow droplets to flow into the temperature-controlled velocity track, enriching the functionality of the surface. In addition, based on its excellent controllability and patterning, the surface has been shown to be used in microfluidic circuit chips with self-cleaning properties, which provides new ideas for circuit timing control. This study provides promising prospects for the effective development of multifunctional liquid steering surfaces, lab-on-a-chip, and microfluidic devices.

Size characterization of x-ray tube source with sphere encoded imaging method.

In x-ray imaging, the size of the x-ray tube light source significantly impacts image quality. However, existing methods for characterizing the size of the x-ray tube light source do not meet measurement requirements due to limitations in processing accuracy and mechanical precision. In this study, we introduce a novel method for accurately characterizing the size of the x-ray tube light source using spherical encoded imaging technology. This method effectively mitigates blurring caused by system tilting, making system alignment and assembly more manageable. We employ the Richardson-Lucy algorithm to iteratively deconvolve the image and recover spatial information about the x-ray tube source. Unlike traditional coded imaging methods, spherical coded imaging employs high-Z material spheres as coding elements, replacing the coded holes used in traditional approaches. This innovation effectively mitigates blurring caused by system tilting, making system alignment and assembly more manageable. In addition, the mean square error is reduced to 0.008. Our results demonstrate that spherical encoded imaging technology accurately characterizes the size of the x-ray tube light source. This method holds significant promise for enhancing image quality in x-ray imaging.

Soliton rain in all-polarization-maintaining mode locked fiber laser.

For the first time the phenomenon of soliton rain is observed in a mode-locked fiber laser with all-polarization-maintaining (all-PM) architecture. The laser is mode-locked using a semiconductor saturable absorber mirror (SESAM) and operates in the all-normal dispersion (ANDi) regime. The operation state of the laser can be switched from dissipative soliton to soliton rain by simply raising the pump power, without any manipulation of the intracavity polarization state given that all components of the resonator are made of PM fibers. The soliton rain generated in the laser is self-starting and replicable, since it occurs in every individual operation of the laser as the pump power is increased to an approximately invariant value.

A novel approach to pulmonary bronchial tree model construction and performance index study.

The demand for respiratory disease and dynamic breathing studies has continuously driven researchers to update the pulmonary bronchial tree's morphology model. This study aims to construct a bronchial tree morphology model efficiently and effectively with practical algorithms. We built a performance index system using failure branch rate, volume ratio, and coefficient of variation of terminal volumes to evaluate the model performance. We optimized the parameter settings and found the best options to build the morphology model, and we constructed a 14th-generation bronchial tree model with a decent performance index. The dimensions of our model closely matched published data from anatomic in vitro measurements. The proposed model is adjustable and computable and will be used in future dynamic breathing simulations and respiratory disease studies.

High performance on-chip polarization beam splitter at visible wavelengths based on a silicon nitride small-sized ridge waveguide.

Due to sensitive scaling of the wavelength and the visible-light absorption properties with the device dimension, traditional passive silicon photonic devices with asymmetric waveguide structures cannot achieve polarization control at the visible wavelengths. In this work, a simple and small polarization beam splitter (PBS) for a broad visible-light band, using a tailored silicon nitride (Si3N4) ridge waveguide, is presented, which is based on the distinct optical distribution of two fundamental orthogonal polarized modes in the ridge waveguide. The bending loss for different bending radii and the optical coupling properties of the fundamental modes for different Si3N4 ridge waveguide configurations are analyzed. A PBS composed of a bending ridge waveguide structure and a triple-waveguide directional coupler was fabricated on the Si3N4 thin film. The TM excitation of the device based on a bending ridge waveguide structure shows a polarization extinction ratio (PER) of ≥ 20 dB with 33 nm bandwidth (624-657 nm) and insertion loss (IL) ≤ 1 dB at the through port. The TE excitation of the device, based on a triple-waveguide directional coupler with coupling efficiency distinction between the TE0 and TM0 modes, shows a PER of ≥ 18 dB with 50 nm bandwidth (580-630 nm) and insertion loss (IL) ≤ 1 dB at the cross port. The on-chip Si3N4 PBS device is found to possess the highest known PER at a visible broadband range and small (43 µm) footprint. It should be useful for novel photonic circuit designs and further exploration of Si3N4 PBSs.

High-responsivity and high-speed black phosphorus photodetectors integrated with proton exchanged thin-film lithium niobate waveguides.

We present a high-performance broadband (450-1550 nm) black phosphorus photodetector based on a thin-film lithium niobate waveguide. The waveguides are fabricated by the proton exchange method with flat surfaces, which reduces the stress and deformation of two-dimensional materials. At a wavelength of 1550 nm, the photodetector simultaneously achieves a high responsivity and wide bandwidth, with a responsivity as high as 147 A/W (at an optical power of 17 nW), a 3-dB bandwidth of 0.86 GHz, and a detectivity of 3.04 × 1013 Jones. Our photodetector exhibits one of the highest responsivity values among 2D material-integrated waveguide photodetectors.

High-Sensitivity Temperature Sensor Based on Fiber Fabry-Pérot Interferometer with UV Glue-Filled Hollow Capillary Fiber.

Optical fiber Fabry-Pérot (FP) interferometer sensors have long been the focus of researchers in sensing applications because of their simple light path, low cost, compact size and convenient manufacturing methods. A miniature and highly sensitive optic fiber temperature sensor using an ultraviolet glue-filled FP cavity in a hollow capillary fiber is proposed. The sensor is fabricated by fusion splicing a single-mode fiber with a hollow capillary fiber, which is filled with ultraviolet glue to form a FP cavity. The sensor has a good linear response in the temperature testing and high-temperature sensitivity, which can be increased with the length of the FP cavity. The experimental results show that the temperature sensitivity reaches 1.174 nm/°C with a high linear response in the range of 30-60 °C. In addition, this sensor is insensitive to pressure and can be highly suitable for real-time water temperature monitoring for ocean research. The proposed ultraviolet glue-filled structure has the advantages of easy fabrication, high-temperature sensitivity, low cost and an arbitrary length of capillary, which has broad application prospects for marine survey technology, biological diagnostics and environmental monitoring.

Multiple Bound State Soliton Pulses in the All Polarization Maintaining Fiber Laser.

The bound state soliton pulse, a novel mode-locked output state of fiber lasers, has been studied extensively to gain a better understanding of soliton interactions and to explain the mechanism behind the generation of mode-locked pulses. In this particular research, we utilized a self-made saturable absorber (SA) consisting of single-walled carbon nanotubes (SWCNT) in a fully polarization maintaining (PM) erbium-doped fiber optical path. Through this setup, we observed various bound state pulse phenomena, including the double bound state with different phase differences, the bound state formed by two double pulse bound states, the multi-pulse bound state, etc. The abundant bound soliton pulse states demonstrated the excellent nonlinear absorption characteristics of the SA as well as the excellent optical properties of the all-PM fiber laser. It contributed to exploring the relationship between sub pulses and mode-locked pulses in the future. Additionally, due to the strong interaction between bound state solitons and the inherent stability of the PM optical path, there was potential for utilizing this setup as a seed source to enhance the stability of high-power fiber lasers.

Laser Powder Bed Fusion of 316L Stainless Steel: Effect of Laser Polishing on the Surface Morphology and Corrosion Behavior.

Recently, laser polishing, as an effective post-treatment technology for metal parts fabricated by laser powder bed fusion (LPBF), has received much attention. In this paper, LPBF-ed 316L stainless steel samples were polished by three different types of lasers. The effect of laser pulse width on surface morphology and corrosion resistance was investigated. The experimental results show that, compared to the nanosecond (NS) and femtosecond (FS) lasers, the surface material's sufficient remelting realized by the continuous wave (CW) laser results in a significant improvement in roughness. The surface hardness is increased and the corrosion resistance is the best. The microcracks on the NS laser-polished surface lead to a decrease in the microhardness and corrosion resistance. The FS laser does not significantly improve surface roughness. The ultrafast laser-induced micro-nanostructures increase the contact area of the electrochemical reaction, resulting in a decrease in corrosion resistance.

Polarization Splitting at Visible Wavelengths with the Rutile TiO2 Ridge Waveguide.

On-chip polarization control is in high demand for novel integrated photonic applications such as polarization division multiplexing and quantum communications. However, due to the sensitive scaling of the device dimension with wavelength and the visible-light absorption properties, traditional passive silicon photonic devices with asymmetric waveguide structures cannot achieve polarization control at visible wavelengths. In this paper, a new polarization-splitting mechanism based on energy distributions of the fundamental polarized modes in the r-TiO2 ridge waveguide is investigated. The bending loss for different bending radii and the optical coupling properties of the fundamental modes in different r-TiO2 ridge waveguide configurations are analyzed. In particular, a polarization splitter with a high extinction ratio operating at visible wavelengths based on directional couplers (DCs) in the r-TiO2 ridge waveguide is proposed. Polarization-selective filters based on micro-ring resonators (MRRs) with resonances of only TE or TM polarizations are designed and operated. Our results show that polarization-splitters for visible wavelengths with a high extinction ratio in DC or MRR configurations can be achieved with a simple r-TiO2 ridge waveguide structure.

Non-uniform droplet deposition on femtosecond laser patterned superhydrophobic/superhydrophilic SERS substrates for high-sensitive detection.

Surface-enhanced Raman scattering (SERS) sensors combined with superhydrophobic/superhydrophilic (SH/SHL) surfaces have shown the ability to detect ultra-low concentrations. In this study, femtosecond laser fabricated hybrid SH/SHL surfaces with designed patterns are successfully applied to improve the SERS performances. The shape of SHL patterns can be regulated to determine the droplet evaporation process and deposition characteristics. The experimental results show that the uneven droplet evaporation along the edges of non-circular SHL patterns facilitates the enrichment of analyte molecules, thereby enhancing the SERS performance. The highly identifiable corners of SHL patterns are beneficial for capturing the enrichment area during Raman tests. The optimized 3-pointed star SH/SHL SERS substrate shows a detection limit concentration as low as 10-15 M by using only 5 µL R6G solutions, corresponding to an enhancement factor of 9.73 × 1011. Meanwhile, a relative standard deviation of 8.20% can be achieved at a concentration of 10-7 M. The research results suggest that the SH/SHL surfaces with designed patterns could be a practical approach in ultratrace molecular detections.

Frequency-domain-resolved investigation of unitary h-shaped pulses.

We experimentally investigate the generation of h-shaped pulse in an all-polarization-maintaining (PM) and all-normal-dispersion (ANDi) mode-locked fiber laser. The generated pulse is demonstrated to be a unitary pulse, instead of a noise-like pulse (NLP). Furthermore, by employing an external filtering system, the obtained h-shaped pulse can be resolved into rectangular-shaped pulses, chair-like pulses, and Gaussian pulses. The authentic AC traces with a double-scale structure of unitary h-shaped pulses and chair-like pulses are observed on the autocorrelator. The chirp of h-shaped pulses is also proved similar to that of DSR pulses. To the best of our knowledge, this is the first time that the existence of unitary h-shaped pulse generation has been confirmed. Moreover, our experimental results reveal the close relationship of formation mechanisms of dissipative soliton resonance (DSR) pulses, h-shaped pulses, and chair-like pulses, which helps to unify the essences of such "DSR-like" pulses.

976†nm all-polarization-maintaining mode-locked fiber laser based on nonlinear polarization evolution.

An all-polarization-maintaining (PM) mode-locked fiber laser based upon nonlinear polarization evolution (NPE) that operates around 976 nm is presented. The NPE-based mode-locking is realized using a special section of the laser which comprises three pieces of PM fibers with specific deviation angles between the polarization axes and a polarization-dependent isolator. By optimizing the NPE section and adjusting the pump power, dissipative soliton (DS) pulses with a pulse duration of ∼6 ps, a spectral bandwidth of >10 nm and a maximum pulse energy of 0.54 nJ are generated. Self-starting, steady mode-locking operation is achievable within a pump power range of ∼2 W. Moreover, by incorporating a segment of passive fiber into the appropriate location in the laser resonator, an intermediate regime between stable single-pulse mode-locking and noise-like pulse (NLP) is realized in the laser. Our work expands the dimension of the research on the mode-locked Yb-doped fiber laser operating around 976 nm.

All-fiber 3.4-W 2.8-µm ultra-short pulse MOPA system seeded by the soliton self-frequency shift of 2-µm pulses.

We report an all-fiber 2.8-µm ultra-short pulse master oscillator power amplifier (MOPA) system seeded by a soliton self-frequency shift from a mode-locked thulium-doped fiber laser. This all-fiber laser source delivers 2.8-µm pulses with an average power of 3.42 W, a pulse width of 115 fs, and a pulse energy of 45.4 nJ. We demonstrate, to the best of our knowledge, the first femtosecond watt-level all-fiber 2.8-µm laser system. A 2.8-µm pulse seed was obtained via the soliton self-frequency shift of 2-µm ultra-short pulses in a cascaded silica and passive fluoride fiber. A novel, to the best of our knowledge, high-efficiency and compact home-made end-pump silica-fluoride fiber combiner was fabricated and used in this MOPA system. Nonlinear amplification of the 2.8-µm pulse was realized, and soliton self-compression was observed accompanied by spectral broadening.

High-energy femtosecond pulse generation from a hybrid mode-locked large-mode-area Er:ZBLAN fiber laser.

We report a hybrid mode-locked fiber laser at 2.8 µm based on a large-mode-area Er:ZBLAN fiber. Reliable self-starting mode-locking is achieved via the combination of nonlinear polarization rotation and a semiconductor saturable absorber. Stable mode-locked pulses with a pulse energy of 9.4 nJ and a pulse duration of 325 fs are generated. To the best of our knowledge, this is the highest pulse energy directly generated from a femtosecond mode-locked fluoride fiber laser (MLFFL) to date. The measured M2 factors are below 1.13, indicating a nearly diffraction-limited beam quality. Demonstration of this laser provides a feasible scheme for the pulse energy scaling of mid-infrared MLFFLs. Moreover, a peculiar multi-soliton mode-locking state is also observed, in which the time interval between the solitons varies irregularly from tens of picoseconds to several nanoseconds.

Mid-infrared ultrashort pulses generated from a hybrid mode-locked Er:ZBLAN fiber laser.

By combining nonlinear polarization rotation (NPR) and semiconductor saturable absorber, we report a hybrid mode-locked Er:ZBLAN fiber oscillator at 2.8 µm. Stable 325-fs mode-locked pulses with an average power of 131 mW and a record signal-to-noise ratio of 79 dB at the fundamental frequency of 55.4 MHz are generated. Numerical simulations are carried out based on the modified coupled nonlinear Schrödinger equations, and offer new insights into the underlying dynamics of pulse generation. The simulations indicate that compared with Er:ZBLAN fiber lasers mode-locked by NPR alone, the hybrid mode-locked Er:ZBLAN fiber oscillator allows a wider range and a lower threshold of the pump power while maintaining the ultrashort pulse width. Moreover, we numerically demonstrate that the hybrid mode-locked oscillator is less sensitive to the variation of polarization states, which will increase its robustness against environmental disturbance. This is the first time that the hybrid mode-locking technique is applied in the mid-infrared, opening up new opportunities for the development of stable ultrafast mid-infrared laser sources and practical applications outside the laboratory.